Why the study?
Does procainamide have a different effect on myocardial contractility compared to lidocaine in an isolated rat heart model?
Does procainamide have a different effect on myocardial contractility compared to lidocaine in an isolated rat heart model?
In an isolated rat heart model, lidocaine exerts a more pronounced negative inotropic effect than procainamide at equivalent concentrations.
Answers are grounded in this paper and cite their sources.
May favor procainamide over lidocaine when contractility matters; hypothesis-generating in isolated rat hearts and requires human validation.
The effect of procainamide and lidocaine on myocardial contractility was studied in an isovolumic isolated rat heart perfusion preparation following the Langendorff technique. As a measure of myocardial contractility, the left ventricular intracavitary pressure and maximum dp/dt were determined and were found to be depressed proportionately to the dose of these agents. At the same concentration, lidocaine showed a more negative inotropic effect than procainamide (although the former seems clinically innocuous at therapeutic doses). In addition, procainamide produced in about one-half of the experiments a biphasic effect characterized by a slight transitory positive inotropic effect followed by a negative inotropic effect.
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El-Nahas et al. (1969) studied this question.
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