Key result
Omental tissue-conditioned media increased cell proliferation and promoted a mesenchymal phenotype in SKOV-3 cells, while decreasing proliferation in OVCAR-3 cells.
Why the study?
Metastasised ovarian cancer spreads to surrounding adipose tissues like the greater omentum, but the role of omental adipocytes in cancer progression remains unclear.
A 3D in-silico model demonstrates that adipocyte-derived factors differentially affect proliferation and epithelial-to-mesenchymal transition in different ovarian cancer cell lines.
Subtle symptoms delay ovarian cancer diagnosis; leaves open need for improved early detection research.
1 Abstract Ovarian cancer is responsible for the most deaths of all gynaecological cancers in the Western world [1]. The symptoms of ovarian cancer are typically subtle and alike to less lethal diseases found more prevalently in the population, frequently resulting in late diagnoses and advanced tumour stages upon treatment initiation [2]. While surgery and platinum-based treatments can be curative, ovarian cancers found at the latter, metastasised stages are likely to be recurrent and more tailored towards palliative care [3]. Metastasised ovarian cancer spreads to surrounding organs and tissues such as the greater omentum [4], a large fat pad composed of adipose tissue stretching from the stomach and hanging over the intestines. The location of this is key in its role towards ovarian cancer and its progression [5]. In this study, we develop a mathematical model to investigate the role that adipocytes found in adipose tissue can have in ovarian cancer progression. Observations of biological experiments from two cell lines create foundations to build a multiscale agent-based model in a Physicell framework. The impact of the adipose derived media concentration, treatment dosage, and initial tumour size are explored to find how these conditions affect the spatio-temporal dynamics of cancer tumours.
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Oliver et al. (2025) studied Ovarian cancer. Omental tissue-conditioned media vs. Unconditioned media was evaluated on Cell proliferation and spatio-temporal dynamics. Omental tissue-conditioned media increased cell proliferation and promoted a mesenchymal phenotype in SKOV-3 cells, while decreasing proliferation in OVCAR-3 cells.
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