The elements of cutaneous aging have been well described and include changes of intrinsic or chronologic aging as well as changes of extrinsic or environmental aging. We also include male pattern alopecia in this category. The current dominance of tretinoin in cutaneous aging therapy is likely to be challenged by newer classes of retinoids, by topical antiandrogens, and by alternative treatments for proliferative lesions.
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Shupack et al. (1990) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: