Key result
High salt intake induced hypertension and cognitive impairment in mice via tau hyperphosphorylation, which was prevented by the angiotensin II receptor blocker losartan or EP1 gene knockout.
Why the study?
The involvement of angiotensin II-AT1 and prostaglandin E2-EP1 systems in high salt-mediated hypertension and emotional and cognitive impairments remained unclear.
Does losartan or EP1 gene knockout prevent high salt-induced hypertension and cognitive impairment in mice?
Does losartan or EP1 gene knockout prevent high salt-induced hypertension and cognitive impairment in mice?
The Ang II-AT1 and PGE2-EP1 systems mediate high salt-induced hypertension and cognitive impairment, suggesting they could be therapeutic targets for hypertension-induced dementia.
High-salt hypertension and cognitive effects may involve Ang II-AT1/PGE2-EP1 pathways; leaves open therapeutic targets pending clinical validation.
High salt (HS) intake is a known risk factor for hypertension and dementia. Clinical studies have shown that antihypertensive drugs can decrease the incidence of dementia. Accordingly, a strong relationship can be suggested between hypertension and cognitive impairment. It is well-known that angiotensin II (Ang II)-AT1 and prostaglandin E2 (PGE2)-EP1 systems are involved in hypertension and neurotoxicity. However, the involvement of these systems in HS-mediated hypertension and emotional and cognitive impairments remains unclear. Herein, we demonstrated that hypertension and impaired social behavior and object recognition memory following HS intake could be associated with tau hyperphosphorylation, decreased phosphorylation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), and postsynaptic density protein 95 (PSD95) expression in the prefrontal cortex and hippocampus of mice. These changes were blocked by pharmacological treatment with losartan, an Ang II receptor blocker (ARB), or EP1 gene knockout. Our findings suggest that Ang II-AT1 and PGE2-EP1 systems could be novel therapeutic targets for hypertension-induced dementia.
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Kubota et al. (2022) studied Hypertension and cognitive impairment. High salt diet vs. Normal water was evaluated on Systolic blood pressure, social behavior, and object recognition memory. High salt intake induced hypertension and cognitive impairment in mice via tau hyperphosphorylation, which was prevented by the angiotensin II receptor blocker losartan or EP1 gene knockout.
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