Key result
Upregulation of ACE2 and positive modulation of Ang II and Ang 1-7 signaling may be an appropriate strategy for improving cognitive function and treating dementia.
Design
Review
Authors
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May inform trials of ACE2 modulation in cognitive decline; leaves open clinical efficacy.
Modulating the renin-angiotensin system to favor the ACE2-angiotensin (1-7)-Mas receptor axis may protect against cognitive decline and dementia driven by hypertension and aging.
Bodiga et al. (2013) conducted a review in Cognitive impairment and dementia. Upregulation of ACE2 and modulation of Ang II/Ang 1-7 signaling was evaluated. Upregulation of ACE2 and positive modulation of Ang II and Ang 1-7 signaling may be an appropriate strategy for improving cognitive function and treating dementia.
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