Key result
The ACE2/Ang(1-7)/Mas axis constitutes a protective arm of the renin-angiotensin system on the blood-brain barrier, offering potential pharmacological targets for vascular dementia.
Why the study?
The renin-angiotensin system plays complex detrimental and beneficial roles at the blood-brain barrier in vascular dementia, prompting a review of angiotensin effects on cerebral endothelial cells to highlight potential pharmacological targets.
This review highlights the protective role of the ACE2/Ang(1-7)/Mas axis on the blood-brain barrier and identifies potential pharmacological targets for managing vascular dementia.
Ang II brain mechanisms position RAS modulation as a potential vascular dementia target; leaves open clinical trials to establish efficacy.
The effects of the renin-angiotensin system (RAS) surpass the renal and cardiovascular systems to encompass other body tissues and organs, including the brain. Angiotensin II (Ang II), the most potent mediator of RAS in the brain, contributes to vascular dementia via different mechanisms, including neuronal homeostasis disruption, vascular remodeling, and endothelial dysfunction caused by increased inflammation and oxidative stress. Other RAS components of emerging significance at the level of the blood-brain barrier include angiotensin-converting enzyme 2 (ACE2), Ang(1-7), and the AT2, Mas, and AT4 receptors. The various angiotensin hormones perform complex actions on brain endothelial cells and pericytes through specific receptors that have either detrimental or beneficial actions. Increasing evidence indicates that the ACE2/Ang(1-7)/Mas axis constitutes a protective arm of RAS on the blood-brain barrier. This review provides an update of studies assessing the different effects of angiotensins on cerebral endothelial cells. The involved signaling pathways are presented and help highlight the potential pharmacological targets for the management of cognitive and behavioral dysfunctions associated with vascular dementia.
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Noureddine et al. (2020) conducted a review in Vascular dementia. Renin-angiotensin system (RAS) components was evaluated. The ACE2/Ang(1-7)/Mas axis constitutes a protective arm of the renin-angiotensin system on the blood-brain barrier, offering potential pharmacological targets for vascular dementia.
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