Key result
Early pharmacological stress echocardiography with early discharge yielded similar 1-year clinical event rates (27.0% vs 30.7%; p=ns) and lower median costs (3561 vs 3850; p<0.05) than usual care.
Why the study?
Does early pharmacological stress echocardiography followed by early discharge reduce costs and maintain similar clinical outcomes compared to usual care in patients with recent uncomplicated myocardial infarction?
RCT (n=458)
randomized
Yes
Does early pharmacological stress echocardiography followed by early discharge reduce costs and maintain similar clinical outcomes compared to usual care in patients with recent uncomplicated myocardial infarction?
Absolute Event Rate: 27% vs 30.7%
p-value: p=ns
Early pharmacological stress echocardiography with early discharge in uncomplicated MI patients is safe and significantly reduces healthcare costs compared to standard delayed discharge and post-discharge exercise ECG.
Supports early discharge after uncomplicated MI via pharmacological stress echo; extends RCT evidence for safe, lower-cost post-MI care.
AIMS: Risk stratification after uncomplicated acute myocardial infarction is mostly applied by either symptom-limited post discharge exercise electrocardiography or pre-discharge submaximal exercise test. Aim of the present study was to determine if early pharmacological stress echocardiography and discharge within 24 hours of the test in cases without induced myocardial ischemia leads to lower costs and similar clinical outcome during 1 year follow up when compared to clinical evaluation and exercise electrocardiography after discharge. METHODS AND RESULTS: Four-hundred fifty-eight patients from 10 participating centers with a recent uncomplicated myocardial infarction were randomized to pharmacological stress echocardiography on day 3-5 followed by early discharge in the case of negative test result (early discharge strategy) (n=233) or clinical evaluation with hospital discharge on day 7-9 and symptom-limited post-discharge exercise electrocardiography at 2-4 weeks after myocardial infarction (usual care strategy) (n=225). At 1 year follow up there were 63 events (4 deaths, 9 non fatal reinfarctions, 50 chest pains requiring hospitalization) in patients randomized to early discharge, and 69 events (6 deaths, 13 reinfarctions, 50 chest pains requiring hospitalization) in usual care (p=ns). Total median individual costs calculated on the basis of hospitalizations, investigations and interventions during 1 year follow up were 3561 for early discharge strategy vs 3850 for usual care strategy (p<0.05). CONCLUSIONS: Early pharmacological stress echocardiography followed by early discharge in case of negative test result gives similar clinical outcome and lower costs after uncomplicated myocardial infarction than clinical evaluation and delayed post-discharge symptom-limited exercise electrocardiography.
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Alessandro Desideri (2003) conducted an RCT in uncomplicated myocardial infarction (n=458). Early pharmacological stress echocardiography and early discharge vs. Clinical evaluation and delayed post-discharge symptom-limited exercise electrocardiography was evaluated on Clinical events (death, non-fatal reinfarction, chest pain requiring hospitalization) (p=ns). Early pharmacological stress echocardiography with early discharge yielded similar 1-year clinical event rates (27.0% vs 30.7%; p=ns) and lower median costs (3561 vs 3850; p<0.05) than usual care.
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