Key result
Simultaneous administration of rt-PA and low-dose recombinant hirudin reduced the incidence of reocclusion from 100% to <25% in a rabbit thrombus model, whereas unfractionated heparin had no effect.
Why the study?
Does recombinant hirudin combined with rt-PA reduce reocclusion rates in a rabbit iliac artery thrombus model?
Population
Anesthetized rabbits with a copper-coil-induced thrombus model in the iliac artery
Comparison
Simultaneous administration of recombinant… vs Unfractionated heparin at a dose increasing PTT…
Design
Preclinical
Authors
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Does not support clinical use of hirudin-rt-PA; leaves open translation from rabbit model to human thrombolysis.
Does recombinant hirudin combined with rt-PA reduce reocclusion rates in a rabbit iliac artery thrombus model?
Absolute Event Rate: 25% vs 100%
In a preclinical rabbit model, low-dose recombinant hirudin combined with rt-PA significantly improved recanalization and reduced early reocclusion compared to unfractionated heparin.
Rübsamen et al. (2009) studied copper-coil-induced thrombus. recombinant hirudin (r-hirudin) and rt-PA vs. unfractionated heparin and rt-PA was evaluated on incidence of reocclusion. Simultaneous administration of rt-PA and low-dose recombinant hirudin reduced the incidence of reocclusion from 100% to <25% in a rabbit thrombus model, whereas unfractionated heparin had no effect.
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