Why the study?
Does chronic hormone replacement therapy alter the renin-angiotensin system in surgically postmenopausal cynomolgus monkeys?
Population
45 surgically postmenopausal cynomolgus monkeys fed a lipid-lowering diet
Comparison
Conjugated equine estrogen alone or in… vs No hormone replacement therapy
Design
Preclinical
Follow-up
30 months
Authors
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Does not alter HRT guidance; extends mechanistic understanding of estrogen-RAS balance in primates but leaves open human relevance.
Does chronic hormone replacement therapy alter the renin-angiotensin system in surgically postmenopausal cynomolgus monkeys?
In a primate model, chronic estrogen replacement activates renin and increases Ang I, but concurrently reduces ACE activity, preventing an increase in the vasoactive product Ang II.
Brosnihan et al. (1997) studied this question.