Key result
Subacute/chronic myocarditis was associated with a significantly higher extracellular volume in 'normal-appearing' myocardium compared to healthy controls (30.1% vs 27.0%, P=0.004).
Why the study?
To determine whether T1 and T2 mapping techniques could identify diffuse myocardial injuries in normal-appearing myocardium in pediatric patients with clinically suspected myocarditis and evaluate associations with cardiac function.
Do T1 and T2 mapping techniques identify diffuse myocardial injuries in 'normal-appearing' myocardium in pediatric patients with clinically suspected myocarditis?
Comparison
Acute myocarditis vs subacute/chronic myocarditis vs control children
Authors
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T1/T2 mapping may detect diffuse injury in pediatric myocarditis; leaves open diagnostic and prognostic utility pending validation.
Observational (n=46)
Blinded assessors
No
Do T1 and T2 mapping techniques identify diffuse myocardial injuries in 'normal-appearing' myocardium in pediatric patients with clinically suspected myocarditis?
Absolute Event Rate: 30.1% vs 27%
p-value: p=0.004
Cardiac MRI mapping techniques, specifically extracellular volume (ECV), can identify diffuse myocardial injuries in 'normal-appearing' myocardium in pediatric patients with subacute/chronic myocarditis.
Wang et al. (2020) conducted an observational in Clinically suspected myocarditis (n=46). Subacute/chronic myocarditis vs. Healthy controls was evaluated on Extracellular volume (ECV) of 'normal-appearing' myocardium (p=0.004). Subacute/chronic myocarditis was associated with a significantly higher extracellular volume in 'normal-appearing' myocardium compared to healthy controls (30.1% vs 27.0%, P=0.004).
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