Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle
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Why the study?
Do PARS inhibitors reduce infarct size in rabbit models of myocardial and skeletal muscle ischemia-reperfusion injury?
Population
Male New Zealand white rabbits subjected to regional myocardial ischemia and reperfusion in vivo, global…
Comparison
PARS inhibitors or NOS inhibitors administered… vs Vehicle control (saline or 10% DMSO).
Design
Preclinical
Follow-up
2 to 3 hours of reperfusion
Authors
Discussion
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Member takes
Implication
PARS inhibition merits further study in ischemia-reperfusion models; leaves open clinical translation.
Structured PICO
Do PARS inhibitors reduce infarct size in rabbit models of myocardial and skeletal muscle ischemia-reperfusion injury?
P
Population
Male New Zealand white rabbits subjected to regional myocardial ischemia (45 min) and reperfusion (2 h) in vivo, global myocardial ischemia (30 min) and reperfusion (2 h) in isolated hearts, or hind limb ischemia (4 h) and reperfusion (3 h) in vivo.
I
Intervention
PARS inhibitors (e.g., 3-aminobenzamide 10 mg/kg, nicotinamide 20 mg/kg, 4-amino-1,8-naphthalimide 1 mg/kg, 1,5-dihydroxyisoquinoline 1 mg/kg) or NOS inhibitors administered before occlusion or reperfusion.
C
Comparator
Vehicle control (saline or 10% DMSO).
O
Outcome
Infarct size (myocardial and skeletal muscle) determined by p-nitro-blue tetrazolium staining.surrogate
Inhibition of PARS activity reduces infarct size and attenuates contractile dysfunction in rabbit models of ischemia-reperfusion injury, highlighting PARS as a potential therapeutic target.
Cite This Study
Thiemermann et al. (1997) studied this question.
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