Key result
Polyunsaturated fatty acid supplements appeared to improve cardiovascular disease prognosis in patients with end-stage renal disease receiving maintenance dialysis.
Why the study?
The cardiovascular protection benefits of polyunsaturated fatty acid (PUFA) supplements in patients with ESRD receiving maintenance dialysis remain unclear.
Do polyunsaturated fatty acid (PUFA) supplements improve blood pressure, heart rate, heart rate variability, and cardiovascular disease prognosis in patients with ESRD receiving maintenance dialysis?
Meta-Analysis (n=724)
Do polyunsaturated fatty acid (PUFA) supplements improve blood pressure, heart rate, heart rate variability, and cardiovascular disease prognosis in patients with ESRD receiving maintenance dialysis?
PUFA supplementation may improve cardiovascular disease prognosis in patients with end-stage renal disease on maintenance dialysis, though longer-term studies are needed.
Supports PUFA supplementation for better CVD prognosis in dialysis; extends RCT evidence on HRV benefits in ESRD.
OBJECTIVE: Apart from dietary restriction and medical therapy, the benefits of cardiovascular protection offered by polyunsaturated fatty acid (PUFA) supplements in patients with ESRD receiving maintenance dialysis remain unclear. This systematic review and meta-analysis examined the effects of PUFAs on blood pressure, heart rate (HR), HR variability (HRV), and cardiovascular disease (CVD) prognosis. METHODS: We identified randomized controlled trials (RCTs) from Embase, PubMed (including MEDLINE), and Web of Science. We included seven RCTs that involved 724 patients with ESRD receiving dialysis and PUFA supplements. RESULTS: = 0%]). CONCLUSION: PUFA supplements appeared to improve CVD prognosis in patients receiving dialysis. Additional RCTs with longer follow-up periods need to clarify the benefits of PUFA supplements in this patient population.
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Chou et al. (2021) conducted a meta-analysis in end-stage renal disease receiving maintenance dialysis (n=724). polyunsaturated fatty acid (PUFA) supplements was evaluated on blood pressure, heart rate, heart rate variability, and cardiovascular disease prognosis. Polyunsaturated fatty acid supplements appeared to improve cardiovascular disease prognosis in patients with end-stage renal disease receiving maintenance dialysis.
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