Key result
In chronic hemodialysis patients, left ventricular diastolic dysfunction, as measured by the E/e' ratio, was an independent predictor of cardiovascular mortality (HR 1.100).
Why the study?
Do echocardiographic parameters (such as E/e' ratio) predict cardiovascular mortality in chronic hemodialysis patients?
Cohort (n=118)
No
Do echocardiographic parameters (such as E/e' ratio) predict cardiovascular mortality in chronic hemodialysis patients?
Diabetes and diastolic dysfunction (measured by E/e' ratio) are independent predictors of cardiovascular mortality in chronic hemodialysis patients, highlighting the prognostic value of routine echocardiography in this population.
Answers are grounded in this paper and cite their sources.
Supports echocardiography for prognostication in hemodialysis; hypothesis-generating and requires prospective validation before guiding care.
Background: Hemodialysis (HD) patients have high rates of cardiovascular (CV) mortality. Although structural and functional echocardiographic alterations in HD patients have been the subject of several survival analysis studies, the prognostic value of these alterations is not well established. The aim of this study was to determine the prognostic value of echocardiographic parameters in chronic HD patients. Objectives: One hundred eighteen HD patients were clinically evaluated and underwent Doppler echocardiography, being followed for 45.7 ± 13.6 months. The outcome measures were CV mortality. The predictive value of echocardiographic variables was evaluated by Cox regression model and survival curves were constructed using the Kaplan-Meier method and log-rank test to compare them. Results: CV diseases accounted for 46.4% of all deaths during the follow-up period. We found that the event-free survival rates in one and two years were 96.5% and 83.0%, respectively. Diabetes and E/e' ratio were predictors of CV outcome by multivariate analyses. Conclusion: Diabetes and diastolic dysfunction are independent predictors of CV mortality in chronic HD patients.
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Koeda et al. (2014) conducted a cohort in Chronic hemodialysis (n=118). E/e' ratio (diastolic dysfunction) vs. Lower E/e' ratio was evaluated on Cardiovascular mortality (HR 1.100, 95% CI 1.011-1.202, p=0.0267). In chronic hemodialysis patients, left ventricular diastolic dysfunction, as measured by the E/e' ratio, was an independent predictor of cardiovascular mortality (HR 1.100).
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