Key result
Oral polio vaccine exposure in a patient with combined immunodeficiency resulted in vaccine-associated paralytic poliomyelitis, highlighting the risk of live vaccines in cellular immunity defects.
Case Report (n=1)
Highlights that neurologic abnormalities compatible with vaccine-related poliovirus infection may be a first presentation of primary immunodeficiency.
Authors
No takes yet. Share an insight, caveat, or question.
Neurologic deficits after OPV warrant immunodeficiency evaluation; extends recognition of VAPP as possible first presentation of PID.
Shaghaghi et al. (2013) conducted a case report in Combined immunodeficiency with vaccine-associated paralytic poliomyelitis (n=1). Oral polio vaccine was evaluated on Vaccine-associated paralytic poliomyelitis. Oral polio vaccine exposure in a patient with combined immunodeficiency resulted in vaccine-associated paralytic poliomyelitis, highlighting the risk of live vaccines in cellular immunity defects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: