Key result
Antihypertensive drugs impact glucose metabolism differently: α-blockers, ACE inhibitors, ARBs, and CCBs improve insulin resistance, whereas β-blockers and diuretics can impair glucose metabolism.
Why the study?
Hypertension requires long-term medication and antihypertensive drugs affect glucose metabolism, which increases the risk of vascular complications, metabolic disorders, and infection.
Do various antihypertensive drugs affect glucose metabolism in patients with hypertension?
Do various antihypertensive drugs affect glucose metabolism in patients with hypertension?
Different classes of antihypertensive drugs have varying effects on glucose metabolism, highlighting the need for clinicians to consider these metabolic impacts for rational drug selection.
Clinicians should monitor glucose with common drugs; review leaves open precise risk quantification in hypertension.
Abnormal glucose metabolism is a common disease of the endocrine system. The effects of drugs on glucose metabolism have been reported frequently in recent years, and since abnormal glucose metabolism increases the risk of microvascular and macrovascular complications, metabolic disorders, and infection, clinicians need to pay close attention to these effects. A variety of common drugs can affect glucose metabolism and have different mechanisms of action. Hypertension is a common chronic cardiovascular disease that requires long-term medication. Studies have shown that various antihypertensive drugs also have an impact on glucose metabolism. Among them, α-receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers can improve insulin resistance, while β-receptor blockers, thiazides and loop diuretics can impair glucose metabolism. The aim of this review was to discuss the mechanisms underlying the effects of various antihypertensive drugs on glucose metabolism in order to provide reference information for rational clinical drug use.
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Li et al. (2024) conducted a review in Hypertension and abnormal glucose metabolism. Antihypertensive drugs was evaluated. Antihypertensive drugs impact glucose metabolism differently: α-blockers, ACE inhibitors, ARBs, and CCBs improve insulin resistance, whereas β-blockers and diuretics can impair glucose metabolism.
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