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Previous uncontrolled studies have reported the beneficial effects of somatostatin in the treatment of psoriasis. This manuscript reports a double-blind, placebo-controlled study of intravenous somatostatin vs placebo in 21 patients with chronic plaque psoriasis vulgaris. Seven of nine patients receiving somatostatin were found to improve on somatostatin compared to one of eleven patients receiving placebo. It would seem justified to perform further clinical studies on the effects of somatostatin in chronic severe psoriasis.
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Matt et al. (1989) studied this question.
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