Key result
In elderly subjects, type 2 diabetes was significantly associated with increased arterial stiffness (0.92 m/s higher pulse wave velocity) compared to normal glucose metabolism, while walking more than 10,000 steps per day was associated with a 0.2 m/s reduction.
Why the study?
Does increased physical activity reduce arterial stiffness in elderly subjects with normal glucose, prediabetes, or Type 2 Diabetes?
Cross-Sectional (n=570)
No
Does increased physical activity reduce arterial stiffness in elderly subjects with normal glucose, prediabetes, or Type 2 Diabetes?
Mean Difference: 0.92 (95% CI 0.569–1.271)
Absolute Event Rate: 9.33% vs 8.41%
p-value: p=<0.001
Higher physical activity is associated with reduced arterial stiffness in elderly subjects, potentially mitigating the adverse vascular effects of impaired glucose metabolism and type 2 diabetes.
May support activity promotion in elderly diabetes; hypothesis-generating without randomized confirmation.
Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.
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Metsämarttila et al. (2018) conducted a cross-sectional in Normal glucose, prediabetes, or Type 2 Diabetes (n=570). Type 2 Diabetes vs. Normal glucose metabolism was evaluated on Carotid-femoral pulse wave velocity ((cf)PWV) (MD 0.92 m/s, 95% CI 0.569-1.271, p=<0.001). In elderly subjects, type 2 diabetes was significantly associated with increased arterial stiffness (0.92 m/s higher pulse wave velocity) compared to normal glucose metabolism, while walking more than 10,000 steps per day was associated with a 0.2 m/s reduction.
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