HLA antibodies can cause falsely positive reactions in platelet aggregation tests used for screening circulating immune complexes, necessitating adequate control experiments.
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HLA antibodies may confound platelet aggregation assays for immune complexes; leaves open the need for HLA-matched controls in future studies.
Twelve different HLA antisera, detecting antigens of both A and B series and the superspecificities w4 and w6, were tested for platelet-aggregating activity in 75 antiserum-platelet combinations. The correlation between the HLA specificities of the antisera and the aggregating effect on platelets carrying the corresponding antigens was significant (P = 0.011). Because the platelet aggregation test is being used for screening of circulating immune complexes, falsely positive reactions caused by HLA antibodies must be eliminated by adequate control experiments.
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Holmlund et al. (1977) studied this question.
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