Key result
Cardiac amyloidosis was associated with significantly lower peak oxygen consumption (15 vs 33 mL/min/kg; P<0.0001) and reduced myocardial reserve during exercise compared with controls.
Why the study?
Does cardiac amyloidosis impair invasive exercise haemodynamics compared to healthy controls?
Population
44 subjects: 24 with cardiac amyloidosis and 20 CA-negative controls.
Comparison
Symptom-limited, semi-supine exercise test with… vs CA-negative controls
Design
Cross-sectional
Authors
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May constrain exercise recommendations in cardiac amyloidosis; leaves open whether restoring myocardial reserve improves outcomes.
Observational (n=44)
Does cardiac amyloidosis impair invasive exercise haemodynamics compared to healthy controls?
Absolute Event Rate: 15% vs 33%
p-value: p=<0.0001
Cardiac amyloidosis is associated with severely reduced inotropic myocardial reserve, increased ventricular filling pressures, and impaired pulmonary arterial compliance during exercise.
Clemmensen et al. (2017) conducted an observational in Cardiac amyloidosis (n=44). Cardiac amyloidosis vs. Controls without cardiac involvement was evaluated on Peak oxygen consumption (p=<0.0001). Cardiac amyloidosis was associated with significantly lower peak oxygen consumption (15 vs 33 mL/min/kg; P<0.0001) and reduced myocardial reserve during exercise compared with controls.
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