June 17, 2005Journal of Cell Science

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

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Population

Co-transfection model and DM1 fibroblasts

Design

Preclinical

Authors

THThai H. HoBroad Institute RSRajesh S. SavkurCenter for Drug Evaluation and Research MPMichael G. PoulosUniversity of Florida

Discussion

Member takes

Implication

Foci and splicing defects are separable in DM1 models; leaves open whether foci drive pathogenesis and warrants validation before targeting.

Structured PICO

Population

Co-transfection model and DM1 fibroblasts

Intervention

Expression of CUG and CAG repeats

Outcome

Colocalization of RNA foci with MBNL1 and alternative splicing of cTNT and IR pre-mRNAssurrogate

The study demonstrates that in myotonic dystrophy type I, the formation of RNA foci and the disruption of MBNL1-regulated splicing are distinct and separable events.

Cite This Study

Ho et al. (2005) studied this question.

synapsesocial.com/papers/6a7355be452eeadd12c67a37 https://doi.org/10.1242/jcs.02404

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Implication

Foci and splicing defects are separable in DM1 models; leaves open whether foci drive pathogenesis and warrants validation before targeting.

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider