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Confirming earlier work by other investigators in isolated chondrocyte cultures, prostaglandin E2 (PGE2) (25 micrograms/ml) causes rapid inhibition of in vitro articular cartilage proteoglycan synthesis in adult pig cartilage slices. The potential impact of E prostaglandins on articular cartilage should be considered in clinical situations associated with elevated intra-articular prostaglandin levels (trauma, meniscal injury, arthritis, etc.).
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Fulkerson et al. (1983) studied this question.
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