Population
Neonatal rat cardiomyocytes, animal models of ischemic heart disease, human ischemic cardiomyopathy tissue…
Comparison
Inhibitory erbB2 antibody vs Control IgG
Design
Preclinical
Authors
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May inform trastuzumab cardiotoxicity mechanisms; hypothesis-generating and requires human validation before clinical relevance.
Blockade of the erbB2 receptor induces cardiomyocyte death through a mitochondrial pathway dependent on ROS production, providing a mechanistic explanation for trastuzumab-induced cardiomyopathy.
Gordon et al. (2008) studied this question.
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