March 5, 2019AntioxidantsOpen Access

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension

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Why the study?

Pulmonary arterial smooth muscle cell hyperproliferation is key to vascular remodeling in pulmonary hypertension, prompting review of data on reactive oxygen species from NADPH oxidases.

Design

Review

Authors

JHJohn HuetschIntarcia Therapeutics (United States)KSKarthik SureshJohns Hopkins Hospital LSLarissa A. ShimodaJohns Hopkins University

Discussion

Member takes

Implication

ROS role in PH remodeling supports antioxidant exploration; leaves open optimal agents and clinical validation.

Structured PICO

Population

Pulmonary arterial smooth muscle cells in the setting of pulmonary hypertension

Intervention

Reactive oxygen species (ROS) generated from NADPH oxidases

Outcome

Pulmonary arterial smooth muscle cell proliferation and vascular remodeling

This review highlights the mechanistic role of NADPH oxidase-derived reactive oxygen species in driving vascular remodeling in pulmonary hypertension, identifying a potential therapeutic target.

Cite This Study

Huetsch et al. (2019) studied this question.

synapsesocial.com/papers/6a735d374e82b1a46ac67f27 https://doi.org/10.3390/antiox8030056

View Full Paper

Ask AI

Bookmark

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider