Population
Male C57BL/6J mice and primary hepatocytes ex vivo
Comparison
Infusion of 6 mM oleic acid bound to albumin or… vs Saline infusion
Design
Preclinical
Follow-up
3 or 6 hours
Authors
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Animal data on route-specific apoB secretion warrant caution; hypothesis-generating and require human validation before clinical relevance.
Increased fatty acid delivery to the liver in vivo increases secretion of apoB-lipoproteins via post-transcriptional mechanisms, with the route of delivery playing an important role.
Zhang et al. (2004) studied this question.
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