April 1, 2000Journal of Lipid ResearchOpen Access

Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes

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Population

Primary hepatocytes isolated from hamster liver

Design

Preclinical

Authors

CTChangiz TaghibiglouUniversity of Saskatchewan DRDebbie RudyUniversity of Toronto SIStephen C. Van IderstineDalhousie University

Discussion

Member takes

Implication

Hypothesis-generating for apoB degradation pathways in VLDL assembly; leaves open relevance to human dyslipidemia without further validation.

Structured PICO

Population

Primary hepatocytes isolated from hamster liver

Intervention

In vitro treatments including MG132, o-phenanthroline, ALLN, and oleate

Outcome

Intracellular mechanisms of apolipoprotein B (apoB) biogenesis, assembly, secretion, and degradationsurrogate

This preclinical study elucidates the intracellular mechanisms of apoB degradation and VLDL assembly in hamster hepatocytes, highlighting the role of proteasomal and metalloprotease pathways.

Cite This Study

Taghibiglou et al. (2000) studied this question.

synapsesocial.com/papers/6a735d6664cdd4095c2c2832 https://doi.org/10.1016/s0022-2275(20)32397-x

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Implication

Hypothesis-generating for apoB degradation pathways in VLDL assembly; leaves open relevance to human dyslipidemia without further validation.

Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider