Why the study?
Does carboxyl-terminal truncation of apoB impair lipid recruitment and secretion of apoB-containing lipoproteins in rat hepatoma cells?
Does carboxyl-terminal truncation of apoB impair lipid recruitment and secretion of apoB-containing lipoproteins in rat hepatoma cells?
Carboxyl-terminal truncation of apoB reduces lipid recruitment and particle size but does not impair secretion, suggesting low apoB levels in hypobetalipoproteinemia are not due to impaired secretion.
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Preserved secretion with apoB truncations suggests alternative mechanisms for hypobetalipoproteinemia; leaves open human relevance.
McLeod et al. (1994) studied this question.
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