What does this research mean for the field?

Deletion from the carboxyl terminal of apolipoprotein B results in a gradual, stepwise loss of the protein's ability to form buoyant lipoprotein particles. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1991Biochemistry

Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines

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Population

Cultured human (HepG2) and rat (McArdle 7777) liver cell lines

Comparison

Expression of constructs designed to express… vs Comparison among different truncated forms of…

Design

Preclinical

Authors

DGDebra GrahamMetroHealth TKTimothy J. KnottRoswell Park Comprehensive Cancer Center TJTina C. Jones

Discussion

Member takes

Implication

Hypothesis-generating for apo B truncation effects in hypobetalipoproteinemia; leaves open human translation from cell models.

Structured PICO

Population

Cultured human (HepG2) and rat (McArdle 7777) liver cell lines

Intervention

Expression of constructs designed to express truncated forms of apolipoprotein B (apo B13, apo B17, apo B23, apo B29, and apo B41)

Comparator

Comparison among different truncated forms of apolipoprotein B

Outcome

Distribution of apolipoprotein B between buoyant lipoprotein (d < 1.25 g/mL) and infranatant (d > 1.25 g/mL) fractionssurrogate

Carboxyl-terminal truncation of apolipoprotein B leads to a progressive loss of its ability to form buoyant lipoprotein particles in liver cell lines, providing mechanistic insight into familial hypobetalipoproteinemia.

Cite This Study

Graham et al. (1991) studied this question.

synapsesocial.com/papers/6a1d705f73c56dd1bd2fae2a https://doi.org/10.1021/bi00236a040

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Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider