What does this research mean for the field?

The length of apolipoprotein B directly determines the lipid content, size, and secretion kinetics of the resulting lipoprotein particles. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1991Journal of Biological ChemistryOpen Access

Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

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Population

Rat hepatoma cell line McA-RH7777 stably transformed with human apoB cDNA constructs

Comparison

Expression of carboxyl-terminally truncated… vs Comparison between different lengths of…

Design

Preclinical

Authors

ZYZemin YaoChina Academy of Space Technology BBB D BlackhartGladstone Institutes MLMacRae F. LintonEast Tennessee State University

Discussion

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Implication

ApoB length dictates lipoprotein secretion kinetics in hepatoma cells; extends mechanistic models but leaves human relevance open.

Structured PICO

Population

Rat hepatoma cell line McA-RH7777 stably transformed with human apoB cDNA constructs

Intervention

Expression of carboxyl-terminally truncated human apoB proteins (apoB18, -B23, -B28, -B31, -B48, and -B53)

Comparator

Comparison between different lengths of truncated apoB proteins

Outcome

Buoyant density, particle size, and secretion kinetics of apoB-containing lipoproteinssurrogate

The length of apolipoprotein B directly determines the lipid content, buoyant density, and secretion kinetics of lipoprotein particles in a hepatoma cell model.

Cite This Study

Yao et al. (1991) studied this question.

synapsesocial.com/papers/6a1d705f73c56dd1bd2fae2c https://doi.org/10.1016/s0021-9258(18)49988-7

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Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider