January 1, 1985Journal of Lipid ResearchOpen Access

Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat.

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Population

Rat livers perfused with recycled, serum-containing medium plus [3H]leucine, and in vivo rats

Design

Preclinical

Authors

HWH.G. WindmuellerNational Institutes of Health ASAlbert E. SpaethNational Institutes of Health

Discussion

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Implication

Regulated apoB isoform ratios may modulate VLDL-triglyceride secretion in rats; leaves open translation to human lipid metabolism.

Structured PICO

Population

Rat livers perfused with recycled, serum-containing medium plus [3H]leucine, and in vivo rats

Intervention

Perfusion with recycled, serum-containing medium plus [3H]leucine; different diets; serum-free perfusate

Outcome

Biosynthesis and metabolism of apolipoprotein B forms (B-48, B-95, B-100) and their correlation with triglyceride secretion ratesurrogate

Hepatic VLDL production in the rat involves the regulated biosynthesis of three forms of apoB (B-48, B-95, B-100) with divergent metabolism, suggesting a mechanism for regulating plasma triglyceride levels.

Cite This Study

Windmueller et al. (1985) studied this question.

synapsesocial.com/papers/6a718c6126a7f98052ddda89 https://doi.org/10.1016/s0022-2275(20)34406-0

View Full Paper

Ask AI

Bookmark

Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider