May 10, 2006Journal of Lipid ResearchOpen Access

Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat

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Population

5 postmenopausal women

Authors

CZChunyu ZhengDalian Medical University KIKatsunori IkewakiThe Jikei University Hospital BWBrian W. WalshMarquette University

Discussion

Member takes

Implication

Should not yet alter lipid management; hypothesis-generating for apoB-48 effects on hepatic lipoprotein clearance.

Structured PICO

Population

5 postmenopausal women

Intervention

Stable isotope labeling in a constantly fed state with half-hourly administration of almond oil

Outcome

Kinetics (fractional catabolic rates, production rates, residence time) of apoB-48 and apoB-100 in VLDL and IDLsurrogate

Intestinal and hepatic triglyceride-rich lipoproteins share similar metabolic pathways and clearance rates, with high apoB-48 production inhibiting apoB-100 clearance, suggesting a mechanism for apoB-48 atherogenicity.

Cite This Study

Zheng et al. (2006) studied this question.

synapsesocial.com/papers/6a88f4aeeb3171c94f1fedbd https://doi.org/10.1194/jlr.m500528-jlr200

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Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider