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December 17, 2019Työväentutkimus VuosikirjaOpen Access

ApoB48-containing VLDL accumulated and were 3-fold higher over the day in subjects with high versus low plasma triglyceride.

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Why the study?

Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular disease mandated further exploration of the integrated metabolism of chylomicrons and VLDL.

Population

15 subjects with a wide range of plasma triglyceride levels

Design

Metabolic tracer kinetic study with an integrated multi-compartmental model

Authors

EBElias BjörnsonCPC.J. PackardMAMartin Adiels

Discussion

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Overview

Does not support changes in triglyceride management; extends kinetic modeling but leaves clinical translation open.

Structured PICO

P
Population
15 human subjects with a wide range of plasma triglyceride levels (normo- and hypertriglyceridemic)
O
Outcome
Kinetics of apoB48- and apoB100-containing particles in the chylomicron and VLDL density intervalssurrogate

ApoB48-containing particles comprise about 20-25% of circulating VLDL and accumulate as slowly cleared remnants in individuals with elevated triglycerides, providing a metabolic mechanism for increased CHD risk.

Cite This Study

Björnson et al. (2019) studied this question.

synapsesocial.com/papers/6a712e6ce71d69abee0917f6https://doi.org/10.1111/joim.13017
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