Why the study?
How does a fat-containing meal affect the concentrations of triglyceride-rich lipoproteins containing apo B-48 and apo B-100 in healthy young men?
Population
Healthy young normolipidemic men
Comparison
An ordinary meal containing one-third of daily… vs Postabsorptive state (baseline)
Design
Other
Follow-up
12 hours
Key result
After ingestion of a fat-containing meal, about 80% of the increase in triglyceride-rich lipoprotein particles occurred in apo B-100-containing VLDL rather than apo B-48-containing chylomicrons.
Authors
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Postprandial lipemia after ordinary meals is driven mainly by hepatogenous VLDL; leaves open whether this accumulation contributes to atherogenicity.
Observational (n=7)
No
How does a fat-containing meal affect the concentrations of triglyceride-rich lipoproteins containing apo B-48 and apo B-100 in healthy young men?
Effect estimate: r2 = 0.80
p-value: p=< 0.01
Following a fat-containing meal, the predominant accumulation of triglyceride-rich lipoproteins occurs in VLDL rather than chylomicrons, highlighting the potential atherogenicity of postprandial lipoproteins.
Schneeman et al. (1993) conducted an observational in Normolipidemic (n=7). Fat-containing meal vs. Fasting state (baseline) was evaluated on Concentration of triglyceride-rich lipoproteins containing apo B-48 and apo B-100 (r2 = 0.80, p=< 0.01). After ingestion of a fat-containing meal, about 80% of the increase in triglyceride-rich lipoprotein particles occurred in apo B-100-containing VLDL rather than apo B-48-containing chylomicrons.
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