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February 1, 1995Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

The peak plasma level of RP was delayed compared with the peak plasma concentration of apoB-48, suggesting that retinyl ester labeling of chylomicrons is questionable as a means of quantifying postprandial triglyceride-rich lipoproteins of intestinal origin.

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Population

Normolipidemic healthy men

Comparison

Mixed meal type of oral fat load supplemented… vs Fasting state (baseline)

Design

Other

Follow-up

9 hours

Authors

FKFredrik KarpeMBMax BellJBJohan Björkegren

Discussion

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Overview

Questions retinyl ester labeling for intestinal TRL quantification; leaves open validation of alternatives like apoB-48 in postprandial studies.

Structured PICO

P
Population
Normolipidemic healthy men
I
Intervention
Mixed meal type of oral fat load supplemented with vitamin A
C
Comparator
Fasting state (baseline)
O
Outcome
Levels of apoB-48, apoB-100, and retinyl palmitate (RP) in fractions of triglyceride-rich lipoproteinssurrogate

Retinyl ester labeling may not be a reliable method for quantifying postprandial triglyceride-rich lipoproteins of intestinal origin due to delayed peak plasma levels compared to apoB-48.

Cite This Study

Karpe et al. (1995) studied this question.

synapsesocial.com/papers/6a82c20988f77a62c2a0cc44https://doi.org/10.1161/01.atv.15.2.199
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