September 1, 1991Journal of Clinical InvestigationOpen Access

Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.

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Why the study?

Does retinyl palmitate transfer to other lipoprotein particles when chylomicron remnants are not produced in LpL-deficient individuals?

Structured PICO

Does retinyl palmitate transfer to other lipoprotein particles when chylomicron remnants are not produced in LpL-deficient individuals?

Population

10 subjects: 3 familial type I hyperlipoproteinemic patients, 4 lipoprotein lipase (LpL)-deficient heterozygotes, and 3 controls on a metabolic research unit.

Intervention

Fat load (16% of total daily calories in type I patients, 40% in heterozygotes and controls) plus 60,000 U/m2 vitamin A

Comparator

Controls receiving 40% fat load plus 60,000 U/m2 vitamin A

Outcome

Triglyceride (TG) and retinyl palmitate (RP) levels in chylomicron and nonchylomicron fractionssurrogate

Retinyl palmitate is an appropriate representative marker for intestinally derived particles in LpL-deficient or partially deficient individuals, as it does not significantly transfer from chylomicrons to other particles.

Discussion

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Implication

Supports RP as marker for intestinal lipoproteins in LpL deficiency; leaves open prospective validation before wider use.

Cite This Study

Sprecher et al. (1991) studied this question.

synapsesocial.com/papers/6a23dd5a79f83c44dfd33647 https://doi.org/10.1172/jci115402

View Full Paper

Ask AI

Bookmark

Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.

Structured PICO

Discussion

Implication

Cite This Study

Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider