Key result
Chylomicron remnant clearance half-times were prolonged in endogenous hypertriglyceridemia (50.7 min) and Type 3 hyperlipoproteinemia (611.9 min) compared to normal subjects (14.1 min).
Why the study?
Does chylomicron remnant clearance differ between normal subjects, those with endogenous hypertriglyceridemia, and those with apoE E2/2 phenotype?
Population
24 adult male subjects divided into three groups: normal plasma triglyceride levels, endogenous…
Comparison
Oral administration of vitamin A and Lipomul vs Comparison across the three groups
Design
Cohort
Follow-up
10-12 hours
Authors
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Impaired remnant clearance may elevate cardiovascular risk in hypertriglyceridemia; leaves open whether enhancing clearance improves outcomes.
Observational (n=24)
Does chylomicron remnant clearance differ between normal subjects, those with endogenous hypertriglyceridemia, and those with apoE E2/2 phenotype?
Chylomicron remnant clearance is delayed in endogenous hypertriglyceridemia and severely impaired in subjects with apoE E2/2 phenotype, likely due to VLDL overproduction and structural apoE abnormalities, respectively.
Cortner et al. (1987) conducted an observational in Hyperlipoproteinemia (n=24). Endogenous hypertriglyceridemia or apoE phenotype E2/2 vs. Normal plasma triglyceride levels was evaluated on Half-times for retinyl palmitate clearance from the chylomicron remnant fraction (T1/2 REMNANT). Chylomicron remnant clearance half-times were prolonged in endogenous hypertriglyceridemia (50.7 min) and Type 3 hyperlipoproteinemia (611.9 min) compared to normal subjects (14.1 min).
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