Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants
Population
12 healthy men aged 22 to 45 years
Design
Other
Follow-up
24 hours
Authors
Discussion
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Overview
Limited remnant conversion from large chylomicrons may affect clearance; leaves open margination's role in postprandial lipemia.
Structured PICO
P
Population
12 healthy men aged 22 to 45 years
I
Intervention
Fatty meal with retinyl palmitate (RP) followed by plasmapheresis and re-injection of RP-rich plasma 24 h later; a second study involved a bolus dose of a triglyceride emulsion (Intralipid) injected shortly after the RP-labeled plasma
O
Outcome
In vivo transformation of larger-sized chylomicrons and chylomicron remnants to smaller-sized remnants (measured by RP content in whole plasma and Svedberg flotation rate fractions)surrogate
The formation of small chylomicron remnants from larger species is limited, and large chylomicrons show signs of margination to the vascular endothelium.
Cite This Study
Karpe et al. (1997) studied this question.