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February 1, 1997Journal of Lipid ResearchOpen Access

In the postprandial state, large and small VLDL were enriched with apoE, C-I, and cholesterol, but depleted of apoC-II, with changes being more pronounced in hypertriglyceridemic subjects.

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Why the study?

Does a fat-rich mixed meal alter VLDL composition in healthy men?

Population

13 healthy men (10 normotriglyceridemic and 3 hypertriglyceridemic)

Comparison

Fat-rich mixed meal vs Fasting state (baseline before meal)

Design

Other

Follow-up

Measured at 2-h intervals after the meal

Authors

JBJohan BjörkegrenAHAnders HamstenRMR W Milne

Discussion

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Overview

Postprandial VLDL compositional shifts may promote atherogenesis in hypertriglyceridemia; hypothesis-generating and requires prospective validation before clinical implications.

Structured PICO

Does a fat-rich mixed meal alter VLDL composition in healthy men?

P
Population
13 healthy men (10 normotriglyceridemic and 3 hypertriglyceridemic)
I
Intervention
Fat-rich mixed meal (1,000 kCal with 60.2 E% from fat)
C
Comparator
Fasting state (baseline before meal)
O
Outcome
Changes in VLDL composition (apoE, C-I, C-II, C-III, triglycerides, phospholipids, and cholesterol) in large and small VLDLsurrogate

Postprandial lipemia induces transient compositional alterations in VLDL that may link these lipoproteins to the formation of atherosclerosis.

Cite This Study

Björkegren et al. (1997) studied this question.

synapsesocial.com/papers/6a7100a93ce530166bc2fc8fhttps://doi.org/10.1016/s0022-2275(20)37443-5
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