What question did this study set out to answer?

To assess changes in the concentration, particle size, and chemical composition of plasma VLDL subfractions and LDL following a fatty meal in normotriglyceridemic and hypertriglyceridemic subjects.

February 1, 1979Journal of Lipid ResearchOpen Access

Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.

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Why the study?

Does a fatty meal alter plasma VLDL and LDL content, composition, and size in normotriglyceridemic and hypertriglyceridemic subjects?

Population

Normotriglyceridemic (NTG) and hypertriglyceridemic (HTG) (type IV) subjects

Comparison

Fatty meal consumption vs Fasting state

Design

Cross-sectional

Follow-up

Postprandial

Authors

TRT.G. RedgraveThe University of Western Australia LCL. A. CarlsonUppsala University

Discussion

Member takes

Implication

Postprandial hyperlipidemia may reflect enlarged VLDL and chylomicron remnants rather than particle number; leaves open causal CVD links in cross-sectional data.

Key Points

To assess changes in the concentration, particle size, and chemical composition of plasma VLDL subfractions and LDL following a fatty meal in normotriglyceridemic and hypertriglyceridemic subjects.
Isolated four VLDL subfractions of decreasing flotation rate (Sf) and LDL using density gradient preparative ultracentrifugation from normotriglyceridemic and type IV hypertriglyceridemic subjects.
Quantified particle counts, diameters, and biochemical composition in both fasting and postprandial states after administration of a fatty meal.
Postprandial hyperlipidemia resulted from the accumulation of chylomicron remnants and an increase in particle diameter within the largest VLDL subfraction, rather than an increase in total particle number.
Type IV hypertriglyceridemic subjects exhibited higher total VLDL particle counts, a shift toward larger VLDL diameters, and LDL enriched with apoprotein B that displayed greater diameter, density, and protein-to-phospholipid ratios compared to controls.

Structured PICO

Does a fatty meal alter plasma VLDL and LDL content, composition, and size in normotriglyceridemic and hypertriglyceridemic subjects?

Population

Normotriglyceridemic (NTG) and hypertriglyceridemic (HTG) (type IV) subjects

Intervention

Fatty meal consumption

Comparator

Fasting state

Outcome

Changes in plasma VLDL and LDL content, composition, and sizesurrogate

Postprandial hyperlipidemia involves an increase in VLDL particle size and the presence of chylomicron remnants, with defective degradation of large VLDL to LDL potentially linked to altered apoprotein B content in type IV hypertriglyceridemia.

Cite This Study

Redgrave et al. (1979) studied this question.

synapsesocial.com/papers/6a092f6c2eb609230a15f2cc https://doi.org/10.1016/s0022-2275(20)40633-9

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Implication

Postprandial hyperlipidemia may reflect enlarged VLDL and chylomicron remnants rather than particle number; leaves open causal CVD links in cross-sectional data.

Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider