Kinetic heterogeneity of low density lipoproteins in primary hypertriglyceridemia.
Population
9 patients with primary hypertriglyceridemia.
Design
Case_series
Authors
Discussion
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Member takes
Implication
May suggest LDL kinetic heterogeneity in moderate hypertriglyceridemia; case report leaves open clinical relevance.
Structured PICO
P
Population
9 patients with primary hypertriglyceridemia (5 with moderate hypertriglyceridemia [plasma triglycerides 333-580 mg/dl] and 4 with mild hypertriglyceridemia).
I
Intervention
Equilibrium ultracentrifugation of LDL, separation into subfractions, separate labeling, and reinjection into the patient.
O
Outcome
Fractional catabolic rate (FCR) and turnover rates of LDL subfractions.surrogate
Patients with moderate primary hypertriglyceridemia exhibit kinetic heterogeneity in LDL subfractions, with denser particles showing higher fractional catabolic rates.
Cite This Study
Vega et al. (1986) studied this question.