July 1, 1989Journal of Internal Medicine
Studies on mechanisms for enhanced clearance of low‐density lipoproteins in patients with primary hypertriglyceridaemia
Key result
Autologous LDL clears ~24% faster than normal homologous LDL in primary hypertriglyceridemia.
- n=12
Population
12 patients with primary hypertriglyceridaemia
Comparison
Measurement of turnover rates for autologous LDL vs Measurement of turnover rates for normal…
Design
Other
Authors
Discussion
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Implication
May indicate intrinsic LDL defects in hypertriglyceridaemia; leaves open effects on cardiovascular risk or therapy.
Study Design
Type
Observational (n=12)
Multicenter
Yes
Structured PICO
P
Population
12 patients with primary hypertriglyceridaemia evaluated for simultaneous turnover rates of autologous and normal homologous LDL.
E
Exposure
Measurement of turnover rates for autologous LDL
C
Comparator
Measurement of turnover rates for normal homologous LDL
O
Outcome
Fractional catabolic rates (FCRs) for LDLsurrogate
Main Result
Absolute Event Rate: 0.61% vs 0.49%
In patients with primary hypertriglyceridaemia, autologous LDL is cleared more rapidly than normal homologous LDL, suggesting increased availability of LDL receptors.
Cite This Study
Vega et al. (1989) conducted an observational in Primary hypertriglyceridaemia (n=12). Autologous LDL vs. Normal homologous LDL was evaluated on Fractional catabolic rates (FCRs) for LDL. In patients with primary hypertriglyceridaemia, autologous LDL was cleared more rapidly than normal homologous LDL (fractional catabolic rates 0.61 vs 0.49 pools per day).