February 1, 1976European Journal of Clinical Investigation

Metabolism of Very Low Density Lipoproteins in Hyperlipidaemia: Studies of Apolipoprotein B Kinetics in Man

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Why the study?

What are the kinetic mechanisms of VLDL-B peptide metabolism in patients with endogenous hypertriglyceridaemia compared to healthy controls?

Population

n=30 subjects, including 19 with endogenous hypertriglyceridaemia, 3 with heterozygous familial…

Comparison

Reinjection of autologous radioiodinated VLDL to… vs Healthy subjects and patients with heterozygous…

Design

Cross-sectional

Authors

GSGunnar SigurðssondeCODE Genetics (Iceland)ANA. NicollAbertay University BLB. LewisUppsala University

Discussion

Member takes

Implication

VLDL-B turnover associates with hypertriglyceridaemia severity; cross-sectional data leave causal direction and therapeutic implications open.

Structured PICO

What are the kinetic mechanisms of VLDL-B peptide metabolism in patients with endogenous hypertriglyceridaemia compared to healthy controls?

Population

n=30 subjects, including 19 with endogenous hypertriglyceridaemia (Types V, IV and IIb), 3 with heterozygous familial hyperbetalipoproteinaemia (Type IIa), and 8 healthy subjects.

Intervention

Reinjection of autologous radioiodinated VLDL to study kinetics

Comparator

Healthy subjects and patients with heterozygous familial hyperbetalipoproteinaemia

Outcome

Turnover rate of VLDL-B peptidesurrogate

Endogenous hypertriglyceridaemia is heterogeneous, driven by VLDL overproduction in some patients and reduced clearance in others.

Cite This Study

Sigurðsson et al. (1976) studied this question.

synapsesocial.com/papers/6a2076c204d2adee4bf48caf https://doi.org/10.1111/j.1365-2362.1976.tb00508.x

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Implication

VLDL-B turnover associates with hypertriglyceridaemia severity; cross-sectional data leave causal direction and therapeutic implications open.