Kinetic bases of the primar hperlipidaemias: studies of apolipoprotein B turnover in geneticall defined subjects

50 subjects, comprising 7 normal subjects and 43 hyperlipidaemic patients classified into groups based on family studies and clinical findings (including heterozygous familial hypercholesterolaemia, familial combined hyperlipidaemia, remnant hyperlipoproteinaemia, familial hypertriglyceridaemia, and unclassified hyperlipidaemias).

Injection of autologous 131I-labelled very low density lipoprotein (VLDL) and 125I-labelled low density lipoprotein (LDL)

Normal subjects compared to various genetically defined hyperlipidaemic patient groups

VLDL and LDL apolipoprotein B kinetics (synthetic rate and fractional catabolic rate)surrogate