Why the study?
Is very low-density lipoprotein apolipoprotein B production increased in adult males with familial combined hyperlipidaemia compared to normolipidaemic controls?
Population
8 adult male subjects (4 with familial combined hyperlipidaemia and 4 normolipidaemic controls)
Comparison
[15N]glycine endogenous marker in a 9-hour… vs Normolipidaemic adult male controls
Design
Case-control
Authors
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VLDL apoB overproduction is associated with FCH; hypothesis-generating for mechanism-targeted therapies pending prospective validation.
Is very low-density lipoprotein apolipoprotein B production increased in adult males with familial combined hyperlipidaemia compared to normolipidaemic controls?
Using stable isotope techniques, this study confirms that very low-density lipoprotein apolipoprotein B production is significantly increased in patients with familial combined hyperlipidaemia.
Cortner et al. (1990) studied this question.
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