Why the study?
What are the kinetic characteristics of apoprotein B transport in patients with endogenous hypertriglyceridemia compared to normolipidemic subjects?
What are the kinetic characteristics of apoprotein B transport in patients with endogenous hypertriglyceridemia compared to normolipidemic subjects?
Endogenous hypertriglyceridemia is characterized by overproduction of apoB within a VLDL subclass and preferential direct catabolism of VLDL without conversion to IDL/LDL.
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Supports VLDL-apoB overproduction with direct catabolism in hypertriglyceridemia; extends kinetic models but remains hypothesis-generating for therapy.
Eaton et al. (1983) studied this question.
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