Accumulation of large very low density lipoprotein in plasma during intravenous infusion of a chylomicron-like triglyceride emulsion reflects competition for a common lipolytic pathway.
Why the study?
Does intravenous infusion of a chylomicron-like triglyceride emulsion affect the accumulation of large VLDL in healthy young men?
Population
Healthy young men
Design
Other
Follow-up
60 minutes
Authors
Discussion
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Implication
Chylomicron remnants may impair VLDL conversion; hypothesis-generating for remnant lipoprotein atherogenesis in humans.
Structured PICO
Does intravenous infusion of a chylomicron-like triglyceride emulsion affect the accumulation of large VLDL in healthy young men?
P
Population
Healthy young men
I
Intervention
60-min intravenous infusion of a chylomicron-like triglyceride emulsion
O
Outcome
Responses of two major VLDL subfractions (large VLDL and small VLDL) determined by measuring the concentrations of apoB-100surrogate
Chylomicrons and their remnants impede the normal lipolytic degradation of VLDL, which may indirectly contribute to the generation of atherogenic remnant lipoproteins.
Cite This Study
Björkegren et al. (1996) studied this question.