September 1, 1999Journal of Lipid ResearchOpen Access

Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase

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Population

In vitro model using purified bovine lipoprotein lipase and various lipoproteins, including samples from…

Design

Preclinical

Authors

SXShiqin XiangUmeå University KCKatherine CianfloneInstitut Universitaire de Cardiologie et de Pneumologie de Québec DKDavid KalantMcGill University

Discussion

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Implication

May explain VLDL effects on chylomicron clearance; hypothesis-generating in animals, human studies required.

Structured PICO

Population

In vitro model using purified bovine lipoprotein lipase (LPL) and various lipoproteins (chylomicrons, VLDL, LDL, HDL, TG liposomes), including samples from patients with familial hypercholesterolemia, LPL deficiency, and hypertriglyceridemia.

Intervention

Competition binding assays of different lipoproteins

Outcome

Inhibition of specific binding of (125)I-labeled VLDL to LPL (binding affinity/efficiency, K(i))surrogate

Differences in binding affinity to lipoprotein lipase between chylomicrons and VLDL may explain the paradoxical delay in postprandial chylomicron clearance caused by small changes in fasting VLDL.

Cite This Study

Xiang et al. (1999) studied this question.

synapsesocial.com/papers/6a20b3749e00afa23b234754 https://doi.org/10.1016/s0022-2275(20)33411-8

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Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider