What question did this study set out to answer?

December 1, 1970Journal of Clinical InvestigationOpen Access

Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets

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Why the study?

Does a high-carbohydrate diet alter VLDL-TGFA transport in patients with type IV hyperlipoproteinemia compared to normal subjects?

Population

9 subjects

Comparison

High-carbohydrate diet vs Usual balanced diet

Follow-up

up to 24 hours

Authors

SQSteven H. QuarfordtUniversity of North Carolina at Chapel Hill AFArthur FrankWashington University Medical Center DSDavid M. ShamesUniversity of California, San Francisco

Discussion

Member takes

Implication

May support targeting VLDL clearance in type IV hyperlipoproteinemia; leaves open validation in outcome trials.

Key Points

Investigate plasma triglyceride transport in type IV hyperlipoproteinemia and the influence of carbohydrate-rich diets.
Measured plasma FFA and VLDL-TGFA in subjects after IV pulse-labeling with radiolabeled palmitate.
Utilized multicompartmental models for analysis over 24 hours in both type IV patients and controls.
Assessed transport differences on balanced and high-carbohydrate diets.
Type IV patients exhibited significantly lower fractional transport of VLDL-TGFA compared to controls.
The carbohydrate-induced increase in VLDL-TGFA pool size was similar in both groups.
Findings suggest both defective removal and potential increased production of VLDL-TGFA in patients on high-carb diets.

Structured PICO

Does a high-carbohydrate diet alter VLDL-TGFA transport in patients with type IV hyperlipoproteinemia compared to normal subjects?

Population

9 subjects (2 normal subjects, 5 patients with type IV hyperlipoproteinemia, and 2 patients with type I hyperlipoproteinemia)

Intervention

High-carbohydrate diet (80% of calories from carbohydrate)

Comparator

Usual balanced diet (40% of calories from carbohydrate)

Outcome

Fractional and net transport of VLDL-TGFAsurrogate

The increased VLDL-TGFA pool size in type IV hyperlipoproteinemia appears to be due to defective removal rather than overproduction, while carbohydrate-induced increases are driven by increased production in both patients and controls.

Limitations

Some type IV patients had only a moderate degree of hypertriglyceridemia
Type IV phenotype may not constitute a biochemically homogeneous population

Cite This Study

Quarfordt et al. (1970) studied this question.

synapsesocial.com/papers/6a1febce91899344c12e56cb https://doi.org/10.1172/jci106448

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Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider