Population
Wild-type C57BL/6, apobec-1-/-, ldlr-/-, and [apobec-1-/-, ldlr-/-] mice, and isolated hepatocytes
Comparison
Genetic knockout of LDLR and apobec-1 vs Wild-type C57BL/6, apobec-1-/-, and ldlr-/- mice
Design
Preclinical
Authors
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LDL receptor regulation of apoB-100 production may inform dyslipidemia mechanisms; hypothesis-generating in this animal model, requires human validation.
The LDL receptor directly regulates hepatic apoB-100 production and modulates the secretion of small, triglyceride-rich particles.
Nassir et al. (2004) studied this question.
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