Key result
Inbred apobec-1-/- mice absorb triglyceride normally but secrete triglyceride-rich lipoproteins more slowly than wild-type controls, with preferential degradation of intestinal apoB-100.
Population
apobec-1-/- mice backcrossed into a C57BL/6 background
Comparison
apobec-1 gene knockout vs wild-type congenic controls
Design
Preclinical
Authors
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Apobec-1-/- mouse data suggest subtle intestinal TG secretion defects; leaves open whether apoB-100 degradation influences human postprandial lipemia.
In apobec-1-/- mice, intestinal apoB-100 is preferentially degraded and triglyceride secretion is subtly impaired, leading to the production of larger lipoprotein particles.
Xie et al. (2003) studied this question. apobec-1 deficiency (apobec-1-/- genotype) vs. wild-type congenic controls was evaluated on triglyceride absorption, intestinal apoB expression, and lipoprotein secretion. Inbred apobec-1-/- mice absorb triglyceride normally but secrete triglyceride-rich lipoproteins more slowly than wild-type controls, with preferential degradation of intestinal apoB-100.
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