Key result
Apobec-1 knock-out reduces chylomicron secretion in mice, demonstrating apo-B100 is less efficient than apo-B48.
Population
apobec-1 knock-out (KO) and wild-type (WT) mice
Comparison
Dietary manipulations: low-fat chow… vs Wild-type (WT) mice
Design
Preclinical
Authors
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Does not alter human lipid management; leaves open whether apo-B48 editing confers evolutionary fat-absorption advantages.
The study demonstrates that apo-B mRNA editing to produce apo-B48 provides an evolutionary advantage by enabling more efficient fat absorption during food shortage or low-fat diets.
Kendrick et al. (2001) studied this question. apobec-1 knock-out vs. wild-type mice was evaluated on chylomicron assembly and fat absorption. Apobec-1 knock-out mice exhibited considerably reduced chylomicron secretion after overnight fasting compared with wild-type mice, demonstrating apo-B100 is less efficient than apo-B48 in assembly.
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